Fig 4. Exendin-4 treatment increases C-peptide and pro-insulin secretion in mice transplanted with minimal human islet grafts.

Circulating levels of fasting blood glucose (a) and C-peptide (b) after 15 days of treatment -/+ exendin-4 (20 or 200μg/kg/day). (c) Ratio of fasting C-peptide to fasting blood glucose at day 15 of treatment was calculated for each mouse. (d) Pro-insulin was measured as indicated in methods. Values for each column are expressed as mean ±SD. * p<0, 05, ** p <0, 01, *** p< 0, 001 by one-way ANOVA followed by Bonferroni correction vs. saline treated control.