Fig 7. The acinar cells in the submandibular gland.

A, SHAM; B, OVX; C, OVX + E; D, OVX + iCR. The scale bars in A, B represent 1μm, and in C, D represent 2 μm. The white arrow indicates the cell membrane sag, and the black arrows represent the cell membrane sag. * stand for the lumen. Compared with the SHAM group, obvious swelling occurred in the mitochondria of the OVX group with dissolution and crest fracture, but unlike the lacrimal gland, there was no obvious expansion of the endoplasmic reticulum. Moreover, the cells showed obvious atrophy with membrane sag. In the OVX + E and OVX + iCR groups, the number of mitochondrial lesions decreased, but the number of secretory granules seemed to decrease compared with the SHAM and OVX groups. The indentation of the cell membrane was improved by the two drugs.