Table 4.

Parameter estimates and bootstrap results of the final ferumoxytol PK model

	Final model estimate [%RSE]a	Bootstrap results
		BS estimate	95 % BS CI	% Biasb
V max (mg/h)	16.5 [4.8]	16.4	14.5–18.5	0.7
Km (mg/L)	96.7 [7.2]	95.5	76.3–117	1.3
V1 (L)	2.78 [3.3]	2.78	2.64–2.94	−0.04
Q (L/h)	0.0289 [8.6]	0.0291	0.0230–0.0376	−0.7
V2 (L)	0.348 [11.5]	0.353	0.258–0.482	−1.4
VSLOPE (L/h)	−0.198 [7.8]	−0.197	−0.248 to −0.146	0.2
WGT on V1 (%/kg)	0.614 [24.9]	0.611	0.331–0.896	0.5
V1 change for females (%)	−18.3 [16.7]	−18.5	−23.7 to −12.3	−0.8
WLO on V1 (%/kg weight loss)	7.22 [23.4]	7.33	3.03–11.4	−1.5
Additive error (µg/mL)	1.40 [20.1]	1.40	0.03–1.99	1.7
Proportional error (%CV)	7.85 [1.4]	7.80	6.83–8.84	0.7
${\text{BSV}}_{V_{\text{max}}}$ (%CV)	17.5 [18.2]	17.2	14.0–22.3	1.9
BSVV1 (%CV)	16.8 [16.5]	16.4	14.3–18.4	2.3
BSVV2 (%CV)	52.7 [33.2]	52.7	31.4–79.1	−0.1

PK pharmacokinetics, RSE relative standard error as a percentage, BS bootstrap, CI confidence interval, BSV between-subject variability, CV coefficient of variation (calculated as sqrt(ω ²) × 100)

^aRSE for BSV and residual error given on the variance scale

^bCalculated as (final model estimate − BS estimate)/BS estimate