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. 2014 Dec 22;18(1):pyu014. doi: 10.1093/ijnp/pyu014

Figure 2.

Figure 2.

Effects of the second-generation synthetic cathinone (A) 4-methyl-N-ethcathinone (4-MEC) (1, 3, 10, 30, mg/kg), (B) α‐pyrrolidinopentiophenone (α-PVP) (0.1, 0.3, 1, and 3mg/kg), and the traditional psychostimulant (C) methamphetamine (METH) (0.1, 0.3, 1, and 3mg/kg) on intracranial self-stimulation (ICSS) thresholds. Data represent mean±95% confidence interval and are expressed as a percent change in ICSS thresholds relative to the previous baseline session. N=5, 5, and 4 in A, B, and C, respectively. *Symbols represent P<.05 vs. saline. In C, the confidence interval upper limit (no shown) for the 3-mg/kg dose=153.87.