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. 2014 Dec 19;18(1):pyu025. doi: 10.1093/ijnp/pyu025

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© The Author 2014. Published by Oxford University Press. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.

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Figure 1. — Experiment 1: effects of chronic URB597 treatment on cue-induced reinstatement. (A) Cocaine seeking in a 6h extinction session without cocaine-paired cues and (B) cue-induced reinstatement with reintroduction of the cues in rats administered daily with URB597 (0.3mg/kg i.p.) or vehicle during a 28-day period of abstinence. Note that for reasons of clarity inactive nose-poke responses in A are not shown. Three-way ANOVA followed by Student-Neuman-Keuls post hoc test, **p < 0.01 master cocaine different from yoked saline control, $$p < 0.01 URB-treated different from vehicle-treated control, ##p < 0.01 active different from inactive nose-pokes.