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. 2014 Dec 19;18(1):pyu033. doi: 10.1093/ijnp/pyu033

Figure 1.

Figure 1.

Infusion of anti-BDNF antibody into the mPFC blocks the behavioral effects of ketamine in the FST. Rats received a bilateral infusion into the mPFC of a function-blocking anti-BDNF antibody (1µg/µl) 30min prior to a ketamine injection (10mg/kg i.p.), and immobility in the FST was determined 24 hours following the ketamine injection. (A) Ketamine significantly reduced the immobility time compared to vehicle-treated rats, and pretreatment with the function-blocking anti-BDNF antibody completely blocked this effect. Values are the mean ± SEM (n = 7–11; antibody x drug interaction, F1,37 = 4.158, *p < 0.05). (B and C) Total swim time was divided into two epochs: the first 5 minutes and the second 5 minutes. Ketamine significantly reduced immobility time, which was blocked by the neutralizing antibody in both the first 5 minutes (ANOVA, F3,37 = 3.357, *p < 0.05) and the second 5 minutes (ANOVA, F3,37 = 3.630, *p < 0.05). (D) There was no effect on locomotor activity.