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. 2014 Dec 15;18(1):pyu043. doi: 10.1093/ijnp/pyu043

Figure 1.

Figure 1.

HPA axis activity and FKBP51 alterations in bipolar disorder. (A) Post-dexamethasone salivary cortisol levels; one-way ANOVA followed by Tukey’s post hoc test. (B) Ex vivo GR responsiveness assay. Isolated peripheral blood mononuclear cells were incubated with increasing concentrations of dexamethasone, with assessment of FKBP5 mRNA levels after 24 hours; Kruskall-Wallis followed by Mann-Whitney test and Bonferroni correction. (C) Basal FKBP5 mRNA levels; one-way ANOVA followed by Tukey’s post hoc test. (D) FKBP51 protein levels; Kruskall-Wallis followed by Mann-Whitney test and Bonferroni correction. (E–F) Methylation status of the FKBP5 gene at two specific CpG dinucleotides; one-way ANOVA followed by Tukey’s post hoc test. *p = 0.008 (BD patients vs. controls). RQ: relative quantification.