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. 2014 Dec 15;18(1):pyu043. doi: 10.1093/ijnp/pyu043

Figure 2.

Figure 2.

HPA axis activity and FKBP51 alterations in patients with early- vs. late-stage bipolar disorder. (A) Post-dexamethasone salivary cortisol levels; one-way ANOVA followed by Tukey’s post hoc test. (B) Ex vivo GR responsiveness assay; Kruskall-Wallis followed by Mann-Whitney test and Bonferroni correction. (C) Basal FKBP5 mRNA levels; Kruskall-Wallis followed by Mann-Whitney test and Bonferroni correction. (D) FKBP51 protein levels; Kruskall-Wallis followed by Mann-Whitney test and Bonferroni correction. (E–F) Methylation status of the FKBP5 gene at two specific CpG dinucleotides; one-way ANOVA followed by Tukey’s post hoc test. BD: bipolar disorder.