Table 1.
BPND of [18F]FE-SPA-RQ, Striatal NK-1 Receptor Occupancy, and Plasma Aprepitant Concentrations in Gerbils After oral Aprepitant Administration
| Parameter | Dose of aprepitant | vehicle | 0.03mg/kg | 0.1mg/kg | 0.3mg/kg | 3mg/kg | 30mg/kg |
|---|---|---|---|---|---|---|---|
| (n = 6) | (n = 6) | (n = 5) | (n = 6) | (n = 6) | (n = 4) | ||
| BPND | 1.70±0.09 | 1.50±0.18 | 0.68±0.08 | 0.44±0.10 | 0.37±0.08 | 0.27±0.06 | |
| Occupancy (%) | - | 11.1±11.1 | 59.7±5.6 | 74.9±5.7 | 78.1±5.1 | 85.0±2.8 | |
| Aprepitant concentration (ng/mL) | - | 2.6±0.2 | 7.4±0.8 | 26.2±3.5 | 274.7±10.3 | 3535.6±707.1 | |
Data are expressed as mean ± standard error of the mean.