Table 2.

Striatal NK-1 receptor occupancy by aprepitant and plasma aprepitant concentrations in gerbils after oral aprepitant administration

Parameter	Dose	Time after administration
		0. 5 h	1 h	2 h	4 h	8 h	24 h
		(n = 3)	(n = 3)	(n = 3)	(n = 3)	(n = 3)	(n = 5)
Occupancy (%)	0.3mg/kg	-4.54±3.10	48.8±8.60	91.4±1.20	95.2±0.72	93.0±0.34	67.5±3.31
	3mg/kg	90.6±0.84	98.7±0.21	99.3±0.32	99.0±0.71	99.2±0.26	93.5±1.19
	30mg/kg	99.6±0.08	99.1±0.20	99.3±0.52	99.2±0.44	98.9±0.29	98.6±0.33
Plasma Concentration (ng/mL)	0.3mg/kg	28.5±5.0	72.6±11.9	75.6±8.3	61.4±10.2	37.3±7.6	4.0±0.4
	3mg/kg	205.7±23.1	453.4±18.4	569.6±7.9	649.8±140.1	476.1±69.5	40.5±5.7
	30mg/kg	2070.7±67.9	4438.0±441.9	6883.4±702.4	4949.7±409.7	4061.7±392.7	209.5±40.4

Data are expressed as mean ± SE.