Figure. 2.

Hyperlocomotion and insomnia induced by sleep deprivation (SD) are attenuated by antimanic agents (lithium and aripiprazole), but not by the antidepressant fluoxetine. Locomotor activity and sleep latency were assessed in control (CC) and SD rats after (A and B) an acute injection of lithium (100mg/kg, i.p.), aripiprazole (1mg/kg, i.p.), fluoxetine (10mg/kg, i.p.), or (C and D) a chronic treatment with fluoxetine (10mg/kg/day i.p., for 21 days). Data represent the mean ± S.E.M. of 7–8 rats/group. *p < 0.05, **p < 0.01, ***p < 0.001 vs respective CC group. #p < 0.05, ##p < 0.01, ###p < 0.001 vs SD-vehicle.