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. 2015 Jan 29;18(2):pyu072. doi: 10.1093/ijnp/pyu072

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© The Author 2015. Published by Oxford University Press on behalf of CINP.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Figure 3. — The effects of Trichostatin A (TSA) or 5-azacytidin (5’AZA) injection (intraperitoneally [i.p.]) on chronic intermittent ethanol (CIE)-induced ethanol consumption during withdrawal. The daily changes of ethanol preference or intake before and after CIE are shown. Mice (TSA+CIE; n=12) received daily TSA injections (2.5 µg/g) or (5’AZA+CIE; n=12) daily 5’AZA (2 µg/g) or saline injection (saline+CIE; n=11) 30 minutes before exposure to CIE. Air mice (n=10) were handled in the same way as previously described. Values represent mean±SEM. *P<.05 indicates a significant difference between saline+CIE and saline+air groups; #P<.05 indicates a significant difference between TSA+CIE and saline+CIE groups (posthoc Newman-Keuls test).