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. 2015 Jan 29;18(2):pyu072. doi: 10.1093/ijnp/pyu072

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© The Author 2015. Published by Oxford University Press on behalf of CINP.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Figure 5. — The effect of S-adenosyl-L-methionine (SAM) injection (intraperitoneally [i.p.]) on chronic intermittent ethanol (CIE)-induced ethanol drinking during withdrawal. The daily changes of ethanol preference or intake before and after exposure to CIE are shown. Mice were given an injection of either 100mg/kg (SAMLo, n=10) or 300mg/kg (SAMHi, n=10) of SAM or saline (n=9) injections 30 minutes before daily exposure to CIE. Mice (n=8) that received saline+air were used as control. Values represent mean ± SEM. *P<.05 compared with saline+CIE; ♦ P<.05 indicates a significant difference between the saline+air and saline+CIE (posthoc Newman-Keuls test).