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. Author manuscript; available in PMC: 2015 Apr 1.
Published in final edited form as: Thorax. 2013 Nov 20;69(4):335–345. doi: 10.1136/thoraxjnl-2013-204324

Table 4.

Affinity of p26, 18 and 23 binding to HLA-DR and HLA-DQ molecules

DR1 DR3 DR4 DR7 DR9 DR11 DR13 DR1501 DR1502 DQ6 DQ8
14% 30% 20% 25% 1% 14% 16% 27% 2% 16% 21%
p26 1 83 5 1 0.3 14 38 9 1 16 267
p18 11 nd 0.3 32 nd 3 >456 42 2000 nd nd
p23 1 nd 0.4 8 nd 2 >456 37 4 nd nd

Results are expressed as a relative binding ratio obtained by dividing the IC50 of allergen peptide by that of a reference peptide that binds strongly to the HLA molecule. Lower numbers correspond to a higher binding affinity. Numbers in bold (ratio of 20 or less) = high affinity binding; numbers in italic (ratio 20–100) = moderate binding affinity. Each peptide—major histocompatibility complex combination was evaluated in two independent experiments. Percentages are the frequency of the HLA-DR or HLA-DQ alleles in a Caucasian population calculated from allele frequency net (http://www.allelefrequencies.net): a database and online repository for immune gene frequencies in worldwide populations.

HLA, human leukocyte antigen; nd, not done.