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Cumulative incidence of monotherapy failure in matched samples of sulfonylurea (n=717) versus metformin (n=3585), when followed for up to 5.5 years. All patients were on continuous treatment for at least 12 months. (A) All failure; (B) add on; (C) switch; (D) discontinuation. All graphs with log rank test p<0.001, except D with log-rank test non-significant.
