Table 3.
Description of changes in HbA1c, eGFR, and weight during the study period
| Metformin |
Sulfonylurea |
Meglitinide |
||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Continuous n=13 845 |
Add on n=2814 |
Switch n=572 |
Discontinuation n= 5166 |
Continuous n=684 |
Add on n=369 |
Switch n=125 |
Discontinuation n=293 |
Continuous n=107 |
Add on n=87 |
Switch n=32 |
Discontinuation n=63 |
|
| Index HbA1c, mean±SD | 54.8±11.7 | 59.9±15.1 | 56.8±11.5 | 54.2±11.0 | 56.0±10.2 | 59.4±14.2 | 56.9±9.7 | 55.9±11.0 | 55.8±12.0 | 58.8±13.8 | 57.6±11.0 | 52.9±7.9 |
| Last HbA1c, mean±SD | 50.2±8.1 | 61.4±12.8 | 56.7±12.2 | 50.0±8.1 | 50.9±8.2 | 59.5±12.0 | 57.6±15.3 | 50.5±10.2 | 50.5±10.0 | 59.9±10.7 | 57.5±13.4 | 48.1±6.5 |
| Delta* HbA1c, mean (95% CI) | −4.6; −4.8–−4.4 | 1.5; 0.9–2.1 | −0.08; −1.2–1.1 | −4.1; −4.4–−3.8 | −5.1; −5.9–−4.3 | 0.11; −1.4–1.7 | 0.73; −1.9–3.3 | −5.4; −6.7–−4.0 | −5.4; −7.9–−2.8 | 1.1; −1.8–4.1 | −0.1; −5.1–4.9 | −4.9; −6.8–−2.9 |
| Change† in HbA1c (%) | −8.4 | 2.5 | −0.14 | −7.6 | −9.1 | 0.19 | 1.3 | −9.7 | −9.7 | 1.9 | −0.17 | −9.3 |
| Continuous n=12 569 | Add on N=2456 |
Switch N=526 |
Discontinuation N=4464 |
Continuous N=604 |
Add on N=322 |
Switch N=101 |
Discontinuation N=251 |
Continuous N=96 |
Add on N=72 |
Switch N=28 |
Discontinuation N=56 |
|
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Index eGFR, mean±SD | 84.8±19.9 | 87.8±20.9 | 78.5±21.1 | 84.4±20.5 | 70.3±22.2 | 80.7±22.2 | 74.0±24.7 | 72.9±23.8 | 74.8±23.3 | 80.7±25.2 | 78.2±25.9 | 76.9±23.1 |
| Last eGFR, mean±SD | 84.6±20.9 | 88.2±21.2 | 76.1±24.4 | 84.2±20.3 | 67.9±21.7 | 80.3 ±24.1 | 72.2±23.3 | 70.4±23.1 | 71.9±23.8 | 80.2±23.9 | 74.1±27.5 | 73.2±21.5 |
| Delta* eGFR, mean (95% CI) | −0.14; −0.4–0.1 | 0.38; −0.2–1.0 | −2.4; −3.7–−1.0 | −0.17; −0.6–0.2 | −2.4; −3.4–−1.4 | −0.41; −1.8–0.1 | −1.84; −4.0–0.3 | −2.5; −4.0–−1.0 | −2.9; −5.2–−0.6 | −0.57; −3.6–2.4 | −4.1; −8.1–0.0 | −3.6; −6.0–−1.3 |
| Change† in eGFR (%) | −0.17 | 0.43 | −3.1 | −0.20 | −3.4 | −0.51 | −2.5 | −3.4 | −3.9 | −0.71 | −5.2 | −4.7 |
| Continuous n=13 045 |
Add on N=2644 |
Switch N=525 |
Discontinuation N=4852 |
Continuous N=622 |
Add on N=342 |
Switch N=111 |
Discontinuation N=266 |
Continuous N=105 | Add on N=83 |
Switch N=30 |
Discontinuation N=58 |
|
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Index weight, mean±SD | 90.1±17.2 | 94.2±17.9 | 90.3±17.3 | 90.0±17.5 | 77.9±14.3 | 77.6±13.7 | 77.0±16.4 | 76.6±13.1 | 75.9±14.9 | 83.7±17.0 | 80.7±16.6 | 81.1±15.3 |
| Last weight, mean±SD | 87.5±17.2 | 93.3±18.0 | 88.3±17.6 | 88.9±17.3 | 77.7±14.6 | 79.3±14.3 | 76.3±14.9 | 76.8±13.1 | 75.8±14.8 | 84.4±17.1 | 81.6±17.3 | 80.9±15.1 |
| Delta* weight, mean (95% CI) | −2.5; −2.6–−2.4 | −0.9; −1.1–−0.7 | −2.0; −2.4–−1.6 | −2.1; −2.2–−1.9 | −0.2; −0.5–0.2 | 1.7; 1.4–2.1 | −0.7; −2.7–1.2 | 0.3; −0.2–0.7 | −0.1; −1.0–0.8 | 0.7; 0.0–1.4 | 0.9; −0.7–2.4 | −0.3; −1.2–0.7 |
| Change† in weight (%) | −2.8 | −0.9 | −2.2 | −2.3 | −0.2 | 2.2 | −1.0 | 0.4 | −0.1 | 0.8 | 1.1 | −0.3 |
Changes were calculated using pairwise measurements.
*δ values were calculated by taking the last available value minus index value, and was calculated for HbA1c (mmol/mol), eGFR (mL/min/1.73 m2), and weight (kg).
†Change (%) during the study period was calculated by dividing the δ value by the index value and multiplying by 100.
eGFR, estimated glomerular filtration rate; HbA1c: glycated hemoglobin.