Table 1.
Laboratory investigations at presentation
| Laboratory test | Presentation | Normal ranges |
|---|---|---|
| General haematology | ||
| Haemoglobulin | 12.2 | 13–18 g/dL |
| White cell count | 5.5×109 | 4–11×109/L |
| Platelet count | 148×109 | 150–400×109/L |
| ESR | 112 | 1–14 mm/h |
| Coagulation | ||
| Prothrombin time | 10.3 | 8.9–12 s |
| PTR/INR | 1.0 | 0.9–1.1 |
| APTT | 22 | 21–31 s |
| APTT ratio | 0.9 | 0.8–1.2 |
| Thrombin time | 0.9 | 12–17 s |
| Thrombin time ratio | 1.1 | 0.8–1.2 |
| DRVVT ratio | 1.05 | 0.74–1.1 |
| Lupus anticoagulant | Not detected | |
| Biochemistry | ||
| Sodium serum | 133 | 136–145 mmol/L |
| Potassium serum | 4.4 | 3.6–5.0 mmol/L |
| Urea | 6.4 | 2.0–7.8 mmol/L |
| Creatinine | 78 | 75–122 µmol/l |
| Estimated GFR | 87 | mL/min |
| Total bilirubin serum | 8 | 2–22 µmol/L |
| Alanine aminotransferase | 106 | 10–40 IU/L |
| Aspartate aminotransferase | 50 | 10–40 IU/L |
| γ-Glutamyl transferase | 89 | 8–78 μ/L |
| Alkaline transferase | 51 | 30–130 IU/L |
| Total protein | 67 | 64–83 g/L |
| Albumin | 33 | 35–50 g/L |
| C reactive protein | 142 | 2–7 mg/L |
| Uric acid | 0.306 | 0.21–0.42 mmol/L |
| Ferritin | 649 | 10–160 µg/L |
| Calcium | 2.26 | mmol/L |
| Adjusted calcium | 2.20 | 2.2–2.6 mmol/L |
| Inorganic phosphate | 1.07 | 0.8–1.5 mmol/L |
| Endocrinology | ||
| Free T4 serum | 18.6 | 10–24.5 |
| TSH | 1.44 | 1.44 mIU/L |
| Specialist proteins | ||
| Immunoglobulin G | 10.5 | 5.5–16.5 g/L |
| Immunoglobulin A | 3.37 | 0.8–4 g/L |
| Immunoglobulin M | 1.27 | 0.4–2 g/L |
| Rheumatoid factor | 15 | 0–20 IU/mL |
| Autoimmune serology | ||
| ANA | Negative | |
| IgG ANCA | Negative | |
| Cardiolipin IgG | 6.4 | 0–10 IU/mL |
| Cardiolipin IgM | 132 | 0–10 IU/mL |
| Anti-B2 glycoprotein IgG | 2.5 | 0–10 IU/mL |
| Anti-B2 glycoprotein IgM | 2.5 | 0–10 IU/mL |
| CCP antibody | 1.6 | 0–10 IU/mL |
ANA, antinuclear antibody; ANCA, antineutrophil cytoplasmic autoantibody; APTT, activated partial thromboplastin time; CCP, cyclic citrullinated peptides; DRVVT, dilute Russell's viper venom time; ESR, erythrocyte sedimentation rate; eGFR, estimated-glomerular filtration rate; INR, international normalised ratio; PTR, prothrombin time; TSH, thyroid-stimulating hormone.