Fig. 11.

MCP-1 levels in the urine, kidney and plasma of db/db diabetic mice. Urinary MCP-1 was significantly increased in db/db mice that were diabetic for ∼8 weeks vs. db/m mice that remained nondiabetic. * p < 0.001 vs. db/m mice. However, there were no significant differences between db/m and db/db mice in the concentrations of MCP-1 protein in the kidneys or plasma (data not shown). At the mRNA level, though, MCP-1 was significantly increased in the kidneys of db/db vs. db/m mice. ** p < 0.05 vs. db/m kidneys (n = 10 in both groups).