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TNFR2 mediates TNF-α-induced MCP-1 in podocytes. Compared to a species-matched control antibody, a neutralizing anti-TNFR1 antibody had no significant effect on the induction of MCP-1 by 10 ng/ml TNF-α for 6 h. In contrast, a neutralizing anti-TNFR2 antibody completely prevented the stimulation of MCP-1 protein production. Combination therapy with both neutralizing antibodies had no further effect versus anti-TNFR2 alone. p values are as shown for the relevant comparisons (n = 3).
