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. 2015 Feb 22;28(3):404–413. doi: 10.1002/nbm.3261

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© 2015 The Authors. NMR in Biomedicine published by John Wiley & Sons, Ltd.

This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Clusters before (top row) and after (bottom row) adjustment for depression for the T₁-weighted spin-echo (T1w) versus chronic fatigue syndrome (CFS) disability regression. The voxel threshold for cluster formation was P = 0.005 (T = 2.8). The edges of the thalamus are shown in red. The peak voxel shifted from the left ventrolateral thalamus–internal capsule junction near x = –16, y = –16, z = +12 in the top row to the left prefrontal white matter (WM) near x = –24, y = +30, z = +18 in the bottom row, indicating that depression effects were stronger more rostrally.