Table 3.
Chromosomal Alterations Identified in Transformed Lymphomas
| Tumor no | Case no | Diagnosis | Abberationsa |
|---|---|---|---|
| 45 | 44:1 | DLBCL | −6p22.3 |
| 46 | 44:2 | FL | −6p22.3 |
| 47 | 45:1 | FL | +2p16.1-15, −5q15-q23.2, +6p21.3-12.1, +7, +8, +10p14, −16p13.1-11.2 |
| 48 | 45:2 | DLBCL | +1pter-36.2, +2p16.1-14, −5q15-23.2, +6p21.3-12.1, +7, +8, −9, +10pter-11.2, +11pter-12, +11q14.2-qter, −13pter-q12.3, −16p13.1-11.2, −17p, −18pter-11.2, +18p11.2-qter, −19p13.2-12 |
| 49 | 46:1 | FL | – |
| 50 | 46:2 | DLBCL | −1pter-31.1,+1q21.3-24.3, −3p21.3-21.2, −3q13.3-22.1, −4q, −5pter-p14.1,+7p22.1-14.3, +7q22.1-qter, −8p, +8q13.2-qter,+9q, −11q12.1-13.3, −15, −17p, −19, −20q,+21, −22 |
| 51 | 47:1 | FL | – |
| 52 | 47:2 | DLBCL | +1q21.1-25.3, +5p, −6q23.3-25.2,+12q12-21.1, −16q12.1-23.3 |
| 53 | 48:1 | FL | −1pter-33, +1q25.3-32.1, −1q41-42.3, +2p21-16.2, −3p26.1-25.2, −4pter-16.1, −6p22.1-21.1,+7p22.1-qter,+8, |
| 54 | 48:2 | DLBCL | −1pter-33, +1q25.3-32.1, −1q41-42.3, +2p21-16.2, −3p26.1-25.2,+4p, −6p22.1-21.1,+7p22.1-qter,+8, +9, −10q, −11, +12, −13, +14, −15q, + 17p, +17q, −20q |
| 55 | 49:1 | FL | +3p21.3-21.1, +8q12.1-12.3, + 11 |
| 56 | 49:2 | DLBCL | −1pter-36.2, +3p21.3-21.1, −6p22.1-21.3, −6q13-24.1, +8q12.1-12.3, −9p21.3, −9p.21, −9q33.2-qter, +11, +12p13.3-12.3, −17pter-p.11.2, +17q12-21.3, −17q23.1-25.3, +18pter-q21.3 |
| 57 | 50:1 | FL | +8p11.2-12.1, −8q21.2-22.1, −10q22.2-25.1, −20q11.2-qter |
| 58 | 50:2 | DLBCL | −5q13.3-14.1, −9p21.2-22.1, +9p12-21.2, +12, −14q21.3-22.3 |
| 59 | 51:1 | FL | −1pter-36.2, +1q, +3, + 4p15.3, −4q13.2-21.2, +5, +6pter-21.1, +7, +9, −13q12.3-12.1, −16q21, +18pter-q21.3, −22 |
| 60 | 51:2 | DLBCL | −1pter-33, +1q, +3, +4p15.3, +5, +6pter-21.1, +7, +9, −11pter-13, −12q23.2-qter, −13q12.3-14.3, −15q23, −16q21-23.1, +18pter-q22.1, −19q, −20, −22 |
| 62 | 53:1 | FL | −1pter-12, −4pter-16.1, −7q21.1-22.1, +7q22.1-31.33, +9p13.2-21.1, −11p12-q14.1, +18, −20q, −22 |
| 63 | 53:2 | DLBCL | −1pter-12, +2p-q14.2, −2q23.3-qter, −4pter-16.1, −6p22.1-21.1, −7q21.1-22.1, +7q22.1-31.3, +9p13.2-q21.1, −11p12-q14.1, −15, −17pter-q21.3, +17q21.3-qter, +18, −20q, −22 |
| 65 | 55.1 | FL | +1pter-36.2, +1q, +11, −13q21.1-34, +18, +19 |
| 66 | 55:2 | DLBCL | +1pter-36.2, −3p13-q21.1, −8pter-23.2, −9pter-21.1, +11, −13q21.1-34, +16p13.11-q12.1, + 18, +19 |
| 67 | 56:1 | FL | −1p34.2-12, −4p16.2-15.1, −7q35-36.3, −9pter-13.3, + 9p13.3-qter, −12pter-q13.1, −13, −14q24.3-31.1, −18, −22 |
| 68 | 56:2 | DLBCL | +1pter-p34.2, −1p34.2-12, −2q31.1-32.2, −4p16.2-15.1, −5q13.2-14.3, −7q35-36.3, −9pter-13.3, +9p13.3-qter, −10q23.1-23.3, −12pter-q13.1, −13, −14q24.3-13.1, −17p, +19q, −22 |
| 69 | 57:1 | FL | −1p36.2-35.1, +8, +11q24.2-qter |
| 70 | 57:2 | DLBCL | −1p36.23-35.1, +6p22.3, +8, +11q24.2-qter, +12p13.3-12.3 |
| 71 | 58:1 | FL | −3p26.1-25.1, +3p25.1-22.1, −6q12-24.1, +8, −9p22.1-21.3, −17, −19 |
| 72 | 58:2 | DLBCL | +2p16.3-14, +6pter-q12, −6q12-24.1,+7, −9p22.1-21.3, +13q33.3-34, −17, −19 |
| 73 | 58:3 | DLBCL | +2p16.3-14, +6pter-q12, −6q12-24.1, +7, −9p22.1-21.3, +13q33.3-34, −17, −19 |
| 74 | 59:1 | FL | −1pter-23.3, −4pter-15.2, −7pter-21.3, −11p13-q14.1, −12q24.1-qter, −17, +18, −19, −22 |
| 75 | 59:2 | FL | −1pter-32.3, +1q31.1-qter, +2p23.3-15, −17pter-p12, +18, −19, −22 |
| 76 | 59:3 | FL | −1pter-32.3, +1q23.3-24.2, +2p16.3-14, −3pter-25.3, +3q22.2-qter, −4q31.2-34.1, −6q22.3-24.1,+7q21.1-31.1, +8q, −9p23-21.1, +9q21.1, +11pter-11.2, +11q22.3-23.3, −11q23.3-qter, −13q31.3-qter, −14q21.3-24.2, +15pter-15.1, −15q15.1-qter, −17p, +18 |
| 77 | 59:4 | DLBCL | −1pter-32.3, +1q23.3-24.2, −2p23.1-16.3, +2p16.3-14, −3pter-25.3, +3q22.2-qter, −4p12-q21.1, −4q31.2-34.1, +6pter-24.3, −6p21.1-12.2, −6q14.1-25.2, +7pter-14.1, +7q11.2-32.1, +8q, +9pter-22.3, −9p22.3-21.3, +9q21.1, +9q22.3-33.2, +10p, −10q26.1-qter, +11pter-15.1, +11q22.3-23.3, −11q23.3-qter, −13(homozygot), +15pter-q15.1, −15q15.1-qter, −17p, +18q21.3-23, −19, −22 |
| 78 | 60:1 | FL | −1pter-34.3,+1q22-qter, +11pter-11.2, −14q24.2-qter, −15q14-21.1, −19 |
| 79 | 60:2 | FL | −1pter-34.3, +1q22-qter, +11pter-11.2, −14q24.2-qter, −19, −22 |
| 80 | 60:3 | FL | −1pter-32.3, +1q21.3-qter, +2pter-12, +3p25.1-qter, +4q31.2-qter, +5, −6pter-21.1, +7, +8, +9q21.1-33.3, −10q21.3-qter, −11q12.1-qter, +12q13.3-21.3, +13, −14q23.3-qter, −16, −17p, −19, −22 |
| 81 | 60:4 | FL | −1pter-32.3, +1q21.3-qter, +2pter-12, +4q31.2-qter, +5, −6pter-21.1, +7, +8, +9q21.1-33.3, −10q21.3-qter, −11q12.1-qter, −12q13.3-21.3, +13, −14q23.3-qter, −16, −17p, −19, −22 |
| 82 | 60:5 | DLBCL | −1p, +1q21.2-qter,+2pter-12, +4q31.2-qter, +5, −6p22.3-qter, +7, +8, +9q21.1-33.3, −10, +12p13.1-q21.3, −14q31.3-qter, −17p, +20, −22 |
a
High level amplification is indicated in bold; DLBCL, diffuse large B-cell lymphoma; FL, follicular lymphoma.