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. Author manuscript; available in PMC: 2015 Mar 21.
Published in final edited form as: Prog Mol Biol Transl Sci. 2014 Dec 1;129:1–32. doi: 10.1016/bs.pmbts.2014.10.001

Figure 4. Structure of the paramyxovirus fusion protein.

Figure 4

Figure 4

Figure 4

4.1 Crystal structure of the pre-fusion state of the trimeric fusion protein of PIV5 showing the fusion peptide (purple) in the hydrophobic pocket formed by ae hydrophobic domain (deep green), the HRN domain (deep blue) and the F2 sub-unit (yellow). (PDB ID: 4GIP; Welch et al.70). 4.2 Crystal structure of the post-fusion state of the fusion protein of HPIV3 showing the 6-helix bundle structure formed by the HRN (deep blue) and HRC (red) domains interacting together. (PBDB ID: 1ZTM; Yin et al73). 4.3 Schematic representation of the main domains of a monomer of the cleaved paramyxovirus fusion protein. HRC/HRN: Heptad Repeat C-/N-terminal domain.