Table 2.
Biopsychosocial Characteristics of Depressed IBD Patients
| Total (CD and UC) | CD (N=120) | UC (n= 43) | |
|---|---|---|---|
|
| |||
| PCDAI [Mean (SD)]a | 21.79 (16.87) | ||
| Diarrhea (PCDAI_2) | 2.11 (3.45) | ||
| Weight change (PCDAI_7) | 2.35 (3.52) | ||
| Height change (PCDAI_8) | 2.33 (3.80) | ||
| Abdominal exam (PCDAI_9) | 1.61 (2.69) | ||
| Perianal exam (PCDAI_10) | 0.82 (2.57) | ||
| Extraintestinal Manifestations (PCDAI_11) | 0.43 (1.41) | ||
|
| |||
| +Modified PCDAI [Mean (SD)] | 17.23 (14.36) | ||
|
| |||
| PUCAI [Mean (SD)]a | 25.38 (24.10) | ||
| Rectal Bleeding (PUCAI_2) | 7.25 (10.61) | ||
| Diarrhea/Stool Form (PUCAI_3) | 4.36 (4.32) | ||
| Diarrhea/Stool Frequency (PUCAI_4) | 4.13 (4.79) | ||
| Diarrhea—Nocturnal Stools (PUCAI_5) | 2.75 (4.52) | ||
| Diarrhea Total (PUCAI2-5 SUM) | 17.56 (19.22) | ||
| Activity Level (PUCAI_6) | 3.40 (4.25) | ||
|
| |||
| +Modified PUCAI | 21.75 (22.60) | ||
|
| |||
| Disease severitya [N (%)] | |||
| Inactive | 41 (25.15) | 29 (24.17) | 12 (27.90) |
| Mild | 68 (41.71) | 51 (42.50) | 17 (39.53) |
| Moderate/Severe | 46 (28.22) | 32 (26.67) | 14 (32.55) |
|
| |||
| Daily Steroid Dose (mg)* [Mean (SD)] | 15.07 (17.73) | 12.32 (17.33) | 22.59 (16.89) |
|
| |||
| Steroid dose in previous year (mg) [Mean (SD)] | 1135.32 (1833.28) | 986.39 (1712.96) | 1514.03 (2087.68) |
|
| |||
| Current Medicationsb [N (%)] | |||
| High Dose Steroids | 43 (26.38) | 25 (20.83) | 18 (41.86) |
| Biologics | 52 (31.90) | 38 (31.67) | 14 (25.00) |
| Immunomodulators | 79 (48.47) | 60 (50.00) | 19 (33.90) |
|
| |||
| Biochemical Markers of Inflammation [Mean (SD)] | |||
| Hematocrit | 36.64 (4.05) | 36.80 (3.43) | 36.18 (5.50) |
| ESR (mm/H) | 23.47 (17.68) | 23.90 (17.50) | 22.28 (18.34) |
| Albumin (g/dl) | 3.77 (0.77) | 3.79 (0.74) | 3.68 (0.87) |
| CRP (g/dl)* | 1.41 (2.60) | 1.58 (2.90) | 0.86 (1.47) |
|
| |||
| API Total Score [Mean (SD)] | 20.89 (10.21) | 20.47 (10.48) | 22.36 (9.30) |
|
| |||
| API Total Z-score [Mean (SD)] | 0.03 (0.85) | 0.01 (0.83) | 0.07 (0.91) |
|
| |||
| Psychological Parameters KSADS [N (%)] | |||
| Minor Depression | 60 (36.80) | 43 (35.80) | 17 (39.50) |
| Major Depression | 103 (63.19) | 77 (64.20) | 26 (60.50) |
|
| |||
| CDRS-R [Mean (SD)]* | 46.72 (12.80) | 45.32 (12.26) | 50.65 (13.50) |
|
| |||
| SCARED-C [Mean (SD)] | 23.87 (12.53) | 24.77 (12.36) | 21.29 (12.79) |
|
| |||
| Comorbid Psychiatric Diagnoses [N (%)]c | |||
| GAD | 33 (20.24) | 25 (20.84) | 8 (18.60) |
| Specific Phobia | 21 (12.88) | 16 (13.33) | 5 (11.63) |
| ADHD | 18 (11.04) | 10 (8.33) | 8 (18.60) |
| Separation Anxiety Disorder | 15 (9.20) | 11 (9.17) | 4 (9.30) |
| ODD | 12 (7.36) | 10 (8.33) | 2 (4.65) |
| Social Anxiety | 13 (7.98) | 11 (9.17) | 2 (4.65) |
| OCD | 2 (1.23) | 1 (0.08) | 1 (2.32) |
| Dysthymia | 2 (1.23) | 1 (0.08) | 1 (2.32) |
| PTSD | 1 (0.62) | 0 (0.00) | 1 (2.32) |
| Panic Disorder | 4 (2.45) | 3 (2.50) | 1 (2.32) |
| AN | 3 (1.84) | 2 (1.67) | 1 (2.32) |
| Conduct Disorder | 2 (1.23) | 1 (0.08) | 1 (2.32) |
*
p<0.05
+
Modified scores remove the individual pain item
a
8 patients with incomplete PCDAI
b
No patients on opiates at time of screen
c
GAD: Generalized Anxiety Disorder; ADHD: Attention Deficit Hyperactivity Disorder; ODD: Oppositional Defiant Disorder; OCD: Obsessive Compulsive Disorder; PTSD: Post-Traumatic Stress Disorder; AN: Anorexia Nervosa