Table 3. Mean PROMIS SF, CAT and Legacy Instrument Scores by COPD Exacerbation Status at Enrollment.

	Stable (n=100)	Exacerbation (n=85)
PROMIS SF+	mean (sd)	mean (sd)	p-value
Anger	50 (9)	53 (10)	<0.01
Anxiety	53 (10)	60 (8)	<0.01
Depression	51 (8)	57 (9)	<0.01
Fatigue	55 (9)	63 (8)	<0.01
Pain Behavior	53 (11)	57 (10)	<0.01
Pain Interference	57 (10)	61 (9)	<0.01
Physical Function	37 (6)	34 (7)	<0.01
Discretionary Social Activities	46 (8)	42 (8)	<0.01
Social Roles	44 (9)	38 (9)	<0.01
Global Physical	40 (8)	35 (8)	<0.01
Global Mental	45 (9)	43 (9)	0.07
PROMIS CAT+	mean (sd)	mean (sd)	p-value
Anger	50 (10)	53 (10)	0.02
Anxiety	54 (9)	62 (8)	<0.01
Depression	51 (9)	57 (9)	<0.01
Fatigue	56 (9)	65 (8)	<0.01
Pain Behavior	54 (9)	56 (9)	0.05
Pain Interference	57 (10)	61 (10)	<0.01
Physical Function	38 (6)	35 (7)	<0.01
Discretionary Social Activities	45 (9)	41 (9)	<0.01
Social Roles	43 (9)	39 (9)	<0.01
Legacy Instruments* +	mean (sd)	mean (sd)	p-value
FACIT - Dyspnea
Dyspnea	51 (9)	58 (11)	<0.01
Functional Limitations	50 (8)	55 (10)	0.0019
SGRQ
Symptoms	53 (22)	76 (15)	<0.01
Activities	66 (20)	81 (18)	<0.01
Impact	38 (19)	58 (17)	<0.01
Total	49 (18)	68 (15)	<0.01
PSQI
	8 (5)	9 (4)	0.02
EXACT PRO - Day 1
	30 (13)	45 (10)	<0.01
MMRC - dyspnea
	38 (26)	58 (30)	<0.01

⁺CAT=computer administered items; SF=short forms;

^*SGRQ=St. George's Respiratory Questionnaire; Modified Medical Research Council (MMRC) Dyspnea Scale; FunctionalAssessment of Chronic Illness Therapy (FACIT) Dyspnea Scale; PSQI=Pittsburgh Sleep Quality Index; Exact-PRO= EXAcerbations of Chronic pulmonary disease Tool– Patient Reported Outcome