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. Author manuscript; available in PMC: 2016 Mar 20.
Published in final edited form as: ACS Chem Biol. 2015 Jan 30;10(3):775–783. doi: 10.1021/cb500981y

Figure 2.

Figure 2

Validation of nine selected compounds identified in the HTS as PfENT1 inhibitors. (A) Concentration-dependent rescue by the compounds of PfENT1-HA-CO-expressing fui1Δ yeast from 125 µM 5-FUrd induced death (Table 1). (B) Concentration-dependent growth inhibition of PfENT1-CO expressing purine auxotrophic yeast in 1 mM adenosine media. (C) Concentration-dependent inhibition of [3H]adenosine uptake into PfENT1-CO expressing yeast over 15 min. Mean values of technical replicates from single experiments are shown.