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. Author manuscript; available in PMC: 2016 Mar 20.
Published in final edited form as: ACS Chem Biol. 2015 Jan 30;10(3):775–783. doi: 10.1021/cb500981y

Figure 3.

Figure 3

Interaction of nine selected compounds with P. falciparum. (A) Concentrationdependent inhibition of [3H]adenosine uptake into RBC-free trophozoite-stage P. falciparum over 15 min. Mean values from technical replicates of single experiments are shown. (B and C) Concentration-dependent inhibition of P. falciparum 3D7 strain proliferation by the compounds in the presence of extracellular hypoxanthine at (B) 367 µM or (C) 10 µM. (D) DNA quantification at the indicated time points for the cultures used in panel (E). (E) Parasite morphology from control and 10× IC50 AKR-122 (3) treated cultures at the indicated times. CQ, chloroquine.