Table 2.
Cytotoxicity (CellTiter Blue assay, 1.5 J/cm2), comparative singlet oxygen quantum yields (relative to methylene blue) and partition coefficients in octanol-HEPES buffer (log P) of BODIPYs.
| BODIPY | Dark toxicity (IC50, µM) |
Phototoxicity (IC50, µM) |
ΦΔ | Log P |
|---|---|---|---|---|
| 2a | 148 | 2.0 | 0.72 | 1.04 |
| 2b | > 400 | 3.8 | 0.78 | 0.72 |
| 2c | > 400 | 14.5 | 0.63 | 0.73 |
| 2d | > 400 | 5.0 | 0.55 | 1.50 |
| 2e | > 400 | 4.0 | 0.65 | 1.10 |
| 3a | > 400 | >100 | 0.64 | 1.16 |
| 3b | > 400 | >100 | 0.65 | 0.89 |
| 3c | > 400 | >100 | 0.37 | 1.01 |
| 3d | > 400 | >100 | 0.34 | 1.94 |
| 3e | > 400 | > 100 | 0.43 | 1.88 |