Table 3.
Descriptive information for all KL-VS genotype groups from Cohort 1, Cohort 2 and meta-analysis
| Cohort 1 | Cohort 2 | Meta-analysis | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Noncarrier (n = 167) | KL-VS het. (n = 50) | KL-VS homo. (n = 5) | P-value | Noncarrier (n = 134) | KL-VS het. (n = 58) | KL-VS homo. (n = 8) | P-value | Noncarrier (n = 301) | KL-VS het. (n = 108) | KL-VS homo. (n = 13) | P-value | |
| Age (mean ± SE) | 69.9 ± 0.5 | 71.5 ± 0.9 | 74.2 ± 0.5 | 0.17 | 80.7 ± 0.5 | 80.4 ± 0.8 | 82.1 ± 1.8 | 0.75 | 74.7 ± 0.5 | 76.3 ± 0.8 | 79.1 ± 1.7 | 0.06 |
| Education (mean ± SE) | 17.4 ± 0.4 | 17.4 ± 0.4 | 17.6 ± 1.0 | 0.97 | 15.5 ± 0.3 | 16.0 ± 0.4 | 14.3 ± 1.2 | 0.28 | 16.5 ± 0.2 | 16.6 ± 0.3 | 15.5 ± 0.9 | 0.41 |
| Sex (M/F) | 68/99 | 29/21 | 3/2 | 0.08 | 37/97 | 16/42 | 1/7 | 0.64 | 105/196 | 45/63 | 4/9 | 0.41 |
| Scan type (1.5/3 T) | 18/149 | 4/46 | 0/5 | 0.64 | 134/0 | 58/0 | 8/0 | NA | 152/149 | 62/46 | 8/5 | 0.38 |
| APOE ε4 (0/1) | 127/40 | 42/8 | 3/2 | 0.42 | 111/23 | 45/13 | 8/0 | 0.28 | 238/63 | 87/21 | 11/2 | 0.91 |
Summary statistics for participants in Cohort 1, Cohort 2, and meta-analysis. Age (53–94 years), education (8–28 years), sex (male or female), scan type (1.5 or 3 T MRI), and APOE ε4 carrier status (0 or 1, where 0 = noncarrier and 1 = carrier of 1 or 2 APOE ε4 alleles) are shown. Two-tailed P-values were from ANOVA (continuous traits) or chi-square (categorical variables) tests by genotype. M, male; F, female.