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. 2015 Jan 9;2(3):241–255. doi: 10.1002/acn3.171

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© 2015 The Authors. Annals of Clinical and Translational Neurology published by Wiley Periodicals, Inc on behalf of American Neurological Association.

This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Effects of monoclonal antibodies on NFT formation in tauopathy mice. (A and C) Brain sections from 15-month-old antibody-treated tau784 mice were examined for NFTs by Gallyas silver staining. Ta1505-treated mice showed apparently reduced levels of NFTs (A), whereas Ta4-treated mice exhibited no changes (C). All images were taken from the EC-II/III region. Scale bar, 30 μm. (B and D) Gallyas silver positive cells in an area (220 × 160 μm) of the EC-II/III region were counted. (B) n = 5 for each group. (D) n = 4 for each group. NFT, neurofibrillary tangle; EC, entorhinal cortex.