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. 2015 Jan 9;2(3):241–255. doi: 10.1002/acn3.171

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© 2015 The Authors. Annals of Clinical and Translational Neurology published by Wiley Periodicals, Inc on behalf of American Neurological Association.

This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Effects of monoclonal antibodies on neuronal loss in tauopathy mice. (A and C) Brain sections from 15-month-old antibody-treated tau784 mice were stained with anti-NeuN antibody. Ta1505 injection partially prevented neuronal loss (A), whereas Ta4 injection did not (C). All images were taken from the entorhinal cortex (EC)-II/III region. Scale bar, 30 μm. (B and D) NeuN-positive cells in an area within 1000 μm along the EC-II (the region between the two broken lines) were counted. (B) n = 5 for each group. (D) n = 6 for non-Tg, n = 4 for cont IgG, and n = 5 for Ta4.