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. 2015 Jan 22;12(1):54–67. doi: 10.1007/s11904-014-0245-5

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© The Author(s) 2015

Open Access This article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited.

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Fig. 1 — Liver and kidney lesions detected in SIVsab-infected NHPs. a Severe bridging mononuclear infiltrate peri portal and around the central veins (SIVsab/PTM, HE); b hepatic fibrosis (SIVsab/PTM, HE); c no kidney lessons are detected in SIVagm-infected African green monkeys; d microthrombi in the glomerular capillaries and afferent arterioles (SIVsab/PTM, IHC for fibrinogen); e parietal epithelial cell hyperplasia associated with collapsed capillaries (a condition involved in the development of focal, segmental glomerulosclerosis) (SIVsab/PTM, HE); f interstitial nephritis—diffuse mononuclear infiltration associated with hyaline casts in the renal tubules (SIVsab/PTM, HE); g interstitial pseudogranulomatous nephritis (SIVsab/PTM, HE)—interstitial nephritis with focal collections of lymphocytes with a germinal center-like area surrounded by other mononuclear cells; h interstitial nephritis (detail—dilated tubules with hyaline casts); i interstitial nephritis (detail—dilated tubules with cellular casts—adherent desquamated epithelial cells of the tubule lining (SIVsab/PTM, HE)