Figure 1.

Categorization of transcription factors employed toward de novo HSC generation

TFs employed by Szabo et al (Sz), Pulecio et al (Pu), Pereira et al (Pe), Batta et al (Ba), Doulatov et al (Do), Riddell et al (Ri), and Sandler et al (Sa) are classified into categories based on previously described activities. ‘Heptad’ factors refer to classical hematopoietic TFs known for their physical interactions (Wilson et al, 2010a). Individual loss of function of TFs highlighted in pink has been shown to impair HSC activity.