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. 2015 Mar 17;13:93. doi: 10.1186/s12967-015-0451-y

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© Chen et al.; licensee BioMed Central. 2015

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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FUS-BBB opening confirmation/ immune-response in normal rats and experimental timelines. (A) Gross brain sections to assess Evans blue dye leakage in brain tissue exposed to 5-W FUS-induced BBB opening as well as the combined large-scaled erythrocyte extravasations after 20-W FUS exposure). (B) Population comparison of CD3+CD4+, CD3+CD8+, CD4+CD25+ T lymphocytes in controlled, 5-W FUS-exposed, and 20-W FUS-exposed normal animals. The CD3+CD4+, CD3+CD8+, and CD4+CD25+ cells specifically represent populations of helper T lymphocytes (Th), cytotoxic T lymphocytes (CTL), and regulatory T lymphocytes (Treg), respectively. (n = 7 per group). (C) The experimental timeline.