Table 4.

Mediation Test Results

GWAS- Associated Phenotype	Phenotype-Associated SNP From GWAS (Mapped Gene)	Expressed Gene Associated With SNP (cis, trans)	SNP-Gene R2	SNP-Gene P Value	Gene- Phenotype R2	Gene- Phenotype P Value	SNP-Phenotype β (Controlling for Expression)	Proportion of Mediation of SNP-Phenotype Association by Expression, %
HDL-C	rs7120118 (NR1H3)	DDB2 (cis)	0.0069	1.7×10−9	0.0033	9.1×10−7	0.17	18.0
		MADD (cis)	0.015	2.6×10−19	0.0055	1.9×10−5	0.22	24.0
	rs174546/rs174547/ rs174548	FADS1 (cis)	0.046	9.4×10−56	0.0037	3.1 ×10−8	−0.45	45.8
	(FADS1)	SREBF2 (trans)	0.0054	8.9×10−8	0.015	2.2×10−24	−0.26	21.1
		LDLR (trans)	0.005	2.9×10−7	0.0084	1.1×1012	−0.21	18.6
	rs964184 (ZNF259)	PPM1B (trans)	0.0051	2.3×10−7	0.0017	6.1 ×10−5	−0.073	3.7
		YPEL5 (trans)	0.0056	6.1 ×10−8	0.0085	1.5×10−12	−0.13	7.0
	rs4759375 (SBN01)	CDK2AP1 (cis)	0.0047	6.1 ×10−7	0.0074	1.6×10−6	0.26	10.1
	rs3136441 (F2)	DDB2 (cis)	0.012	1.1×10−15	0.0033	9.1 ×10−7	0.30	32.4
	s2271293/rs16942887 (NUTF2/PSKH1)	DPEP2 (cis)	0.0061	1.3×10−8	0.015	5.9×10−16	0.41	23.2
		SLC12A4 (cis)	0.0046	9.2×10−8	0.0035	4.6×10−4	0.14	8.3
HDL-C	rs255049 (DPEP3)	DPEP2 (cis)	0.0084	2.5×10−11	0.015	5.9×10−16	0.38	43.7
		SLC12A4 (cis)	0.0045	1.2×10−6	0.0035	4.6×10−4	0.11	13.3
LDL-C	rs964184 (ZNF259)	PCSK7 (cis)	0.0038	7.0×10−6	0.0040	3.3×10−4	0.15	7.5
	rs174546 (FADS1)	LDLR (trans)	0.005	2.9×10−7	0.0034	9.6×10−13	−0.35	28.5
		FADS1 (cis)	0.046	9.4×10−56	0.0018	4.4×10−7	−0.72	58.6
Triglycerides	rs10761731 (JMJD1C)	CXCL5 (trans)	0.0061	1.4×10−8	0.012	2.9×10−15	−0.0063	17.0
		ITGB3 (trans)	0.0062	1.2×10−8	0.011	1.3×10−11	−0.0042	11.8
		AQ10 (trans)	0.0067	2.9×10−9	0.0044	3.3×10−5	−0.0046	12.8
		ITGA2B (trans)	0.0051	2.4×10−7	0.02	7.5×10−6	−0.0063	16.6
		CLU (trans)	0.005	2.7×10−7	0.022	9.9×10−23	−0.0066	17.6
	rs174546/rs174558 (FADS1)	FADS1 (cis)	0.046	9.4×10−56	0.0017	2.7×10−6	0.011	47.4
Triglycerides	rs174546/rs174558 (FADS1)	SREBF2 (trans)	0.0054	8.9×10−8	0.017	1.1×10−26	0.0074	27.6
		LDLR (trans)	0.005	2.9×10−7	0.0024	2.8×10−7	0.0038	15.1
	rs4938303 (RPL15P15, BUD13)	PCSK7 (cis)	0.0041	3.64×10−6	0.0047	2.6×10−11	0.0035	5.0
	rs651821 (APOA5)	SREBF2 (trans)	0.0047	6.4×10−7	0.017	1.1×10−26	0.014	9.8
	rs964184 (ZNF259)	PPM1B (trans)	0.0051	2.26×10−7	0.0087	3.0×10−19	0.0055	4.4
		YPEL5 (trans)	0.0056	6.11×10−8	0.027	1.3×10−38	0.0071	5.7

GWAS indicates genome-wide association studies; HDL-C, high-density lipoprotein cholesterol; LDL, low-density lipoprotein cholesterol; R², percent variance explained; SNP, single nucleotide polymorphism; and /, SNP in linkage disequilibrium (R² > 0.8).