Table 5.
eQTLs Among Metabolite-Associated GWAS Single Nucleotide Polymorphisms
| eQTL | Gene Symbol and Locus |
Metabolite Associated With eQTL |
Traits Associated With eQTL in GWAS |
Expressed Gene Associated With eQTL |
|---|---|---|---|---|
| rs1260326 |
GCKR (2p23.3) |
Glucose/mannose | C-reactive protein; triglycerides; LDL cholesterol |
NRBP1* |
| rs174547/ | FADS1 | Arachidonate (20:4n6)/ | HDL cholesterol; | C11orf10*; FADS2*; FADS1*; FEN1*; |
| rs174548 | (11q12.2) | dihomo-linolenate (20:3n3 or n6) | triglycerides | LDLR†; SREBF2† |
| rs3184504 | SW2B3(12q24.12) | Kynurenine | Blood pressure; type 1 diabetes mellitus |
TRAFD1*; ALDH2*; HVCN1*; TCTN1*; ANKRD22†; ARHGEF40†; CD274†; FCGRIA†; GBP1†; GBP4†; GBP5†; GBP7†; IDS†; IFIT3†; IRF9†; MYADM†; PARP14†; PSMB9†; PSTPIP2†; RFX2†; RNF31†; SAMD9L†; SERPINGI†; SRBDI†; STATI†; TRIM22†; UBE2L6†; WDFY2† |
| rs7570971 | RAB3GAP1 (2q21.3) | 1,5-Anhydroglucitol (1,5-AG) | LDL cholesterol | MCM6*; R3HDM1*; IRF8†; TNFRSF21†; ULRA4†; SERPINF1†; DARS† |
| rs964184 | ZNF259 (11q23.3) | DAG 36:2/ TAG 56:3 /X-03094 |
HDL cholesterol | BUD13*; PCSK7*; SIDT2*; TAGLN*; 0BFC2A†; TMEM165†; PPM1B†; YPEL5† |
| rs651821 |
AP0A5 (11q23.3) |
Valine | Triglycerides | TAGLN*; SIDT2*; SREBF2† |
eQTL indicates expression quantitative trait loci; GWAS, genome-wide association studies; HDL, high-density lipoprotein; and LDL, low-density lipoprotein.
*
Denotes cis association with eQTL.
†
Denotes trans association with eQTL.