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. Author manuscript; available in PMC: 2016 Apr 1.
Published in final edited form as: J Immunol. 2015 Feb 25;194(7):3317–3326. doi: 10.4049/jimmunol.1402289

FIGURE 1.

FIGURE 1

OSCAR is a novel SP-D receptor. (A) OSCAR-Fc, LAIR1-Fc, ILT3-Fc and TREM1-Fc binding to different human (h) and rat (r) SP-D isoforms and collagen I (± 5mM Ca2+) in solid-phase (*, P <0.05). (B) Capture of Hyb-246-04 mAb reactive protein from human BAL (n=1 donor) or (C) soluble recombinant hSP-D dodecamer by plate-immobilized OSCAR-Fc (circles) or LAIR1-Fc (triangles) (*, P <0.05). (D) GFP expression from OSCAR-CD3ζ NFAT-GFP reporter cells incubated with recombinant SP-D isoforms in solid- or (E) soluble-phase. Data were performed in triplicate and are representative of three independent experiments.