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. Author manuscript; available in PMC: 2016 Apr 1.
Published in final edited form as: J Immunol. 2015 Mar 4;194(7):3035–3044. doi: 10.4049/jimmunol.1402690

Figure 7. TLR stimulation expands cells bearing shorter CDR3 segments.

Figure 7

A: TLR stimulation selectively expanded B cells with shorter CDR3 segments, particularly among mutated B cells, relative to mean length of 46 bases for unstimulated cells. B: TLR stimulation shifts the frequency distribution of CDR3 lengths towards shorter CDR3s. A: Bars represent mean, error bars represent SEM. B: bars represent sum of the proportion of unique sequences with a CDR3 length in the indicated length range. Columns appear in order of legend. * = p < 0.05. Data represent four independent donors, split across two independent sequencing runs.