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. Author manuscript; available in PMC: 2016 Apr 16.
Published in final edited form as: Neuroscience. 2015 Feb 17;291:128–145. doi: 10.1016/j.neuroscience.2015.02.012

Figure 9. Repeated stress increases fear generalization in adolescent rats.

Figure 9

A) Fear conditioning in adult rats led to increased freezing to the CS+ tone. Stress did not increase this conditioned freezing. B) In adult rats, presentation of the CS+ tone caused suppression of exploration in the open field, while presentation of a distinct tone did not (left). Stress did not facilitate the effects of either tone (right). C) Fear conditioning in adolescent rats led to increased freezing to the CS+ tone. Stress did not increase this conditioned freezing. D) In adolescent rats, presentation of the CS+ tone caused suppression of exploration in the open field (left). Stress facilitated the effects of the distinct tone in adolescent rats (right). Δ Time in center = the difference in center time between the no-tone and tone conditions. * p<0.05 for main effect in two-way repeated measures ANOVA. + p<0.05 post hoc Holm-Sidak test after two-way ANOVA.