TABLE 3.

Age-adjusted odds ratios (OR) and 95% confidence intervals (CI) for the interaction between oxidative stress genes polymorphisms and body mass index (BMI) and postmenopausal breast cancer risk, Long Island Breast Cancer Study Project (1996–1997).

Gene (rs) major/minor alleles BMIa	Homozygous for major allele			At least one copy of minor allele			Multiplicative p
	Cab/Coc	OR	95% CI	Ca/Co	OR	95% CI
CAT (rs1001179) C/T
<25kg/m2	153/199	1.00	reference	106/116	1.00	reference	0.572
25–29.9kg/m2	139/132	1.34	(0.97, 1.86)	85/76	1.23	(0.81, 1.86)
≥30kg/m2	116/98	1.60	(1.13, 2.28)	116/98	1.74	(1.09, 2.77)
COMT (rs4680) G/A
<25kg/m2	64/85	1.00	reference	197/228	1.00	reference	0.086
25–29.9kg/m2	67/49	1.88	(1.13, 3.13)	163/160	1.15	(0.86, 1.55)
≥30kg/m2	59/39	2.12	(1.24, 3.64)	129/108	1.39	(1.00, 1.92)
COMT (rs737865) T/C
<25kg/m2	131/148	1.00	reference	126/164	1.00	reference	0.347
25–29.9kg/m2	107/94	1.28	(0.88, 1.86)	118/114	1.32	(0.92, 1.90)
≥30kg/m2	88/72	1.33	(0.89, 2.00)	98/76	1.74	(1.18, 2.57)
GPX (rs1050450) C/T
<25kg/m2	118/147	1.00	reference	144/165	1.00	reference	0.346
25–29.9kg/m2	102/112	1.15	(0.80, 1.67)	121/98	1.39	(0.98, 1.99)
≥30kg/m2	86/66	1.67	(1.10, 2.52)	103/79	1.54	(1.06, 2.25)
GSTA1 (rs3957356) G/A
<25kg/m2	89/115	1.00	reference	173/200	1.00	reference	0.364
25–29.9kg/m2	71/66	1.39	(0.88, 2.19)	153/143	1.21	(0.88, 1.65)
≥30kg/m2	62/44	1.88	(1.14, 3.09)	128/102	1.47	(1.05, 2.06)
GSTP1 (rs1695) A/G
<25kg/m2	121/152	1.00	reference	135/154	1.00	reference	0.133
25–29.9kg/m2	119/97	1.56	(1.08, 2.26)	105/106	1.09	(0.76, 1.58)
≥30kg/m2	95/64	1.93	(1.28, 2.91)	89/80	1.26	(0.85, 1.86)
GSTM1 (gene deletion)
<25kg/m2	123/152	1.00	reference	120/135	1.00	reference	0.527
25–29.9kg/m2	103/104	1.32	(0.91, 1.91)	111/82	1.46	(0.99, 2.15)
≥30kg/m2	98/84	1.56	(1.06, 2.29)	80/51	1.73	(1.11, 2.69)
GSTT1 (gene deletion)
<25kg/m2	193/231	1.00	reference	49/57	1.00	reference	0.017
25–29.9kg/m2	183/141	1.58	(1.18, 2.13)	35/48	0.85	(0.47, 1.56)
≥30kg/m2	131/107	1.52	(1.09, 2.11)	47/31	1.87	(1.01, 3.48)
MPO (rs2333227) G/A
<25kg/m2	173/178	1.00	reference	88/136	1.00	reference	0.024
25–29.9kg/m2	136/133	1.05	(0.76, 1.46)	90/77	1.84	(1.21, 2.78)
≥30kg/m2	113/91	1.33	(0.93, 1.89)	75/55	2.13	(1.35, 3.36)

^a1-year prior to reference date;

^bCases;

^cControls