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MBD7 binds to highly methylated genomic regions through its MBD motifs, and uses its Stkc domain to bind to IDM3 and IDM2, thus bringing IDM1 to the methylated DNA. The H3K18ac and H3K23ac marks created by IDM1 then allow ROS1 and related DNA demethylases to be recruited to curb methylation spread or to prevent hypermethylation by active demethylation.
