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. Author manuscript; available in PMC: 2016 Mar 19.
Published in final edited form as: Chem Biol. 2015 Mar 5;22(3):355–368. doi: 10.1016/j.chembiol.2015.02.003

Figure 1. 7,8-DHF-Treated Female Mice Are Resistant to Diet-Induced Obesity.

Figure 1

(A) Growth curve of 8-week-old female mice fed with different combinations of diets (**P < 0.01, **P < 0.001, two-way ANOVA versus the same diet feeding, n = 8–10).

(B) Organ weight of female mice that have been fed with HFD and 7,8-DHF for 20 weeks (**P < 0.01, Student's t test, n = 5).

(C) Pictures of H&E staining of inguinal WAT and liver sections from female mice that have been fed with HFD and 7,8-DHF for 20 weeks. Representative results of four different mice from each treatment are shown. Scale bar represents 50 mm.

(D) Adipocyte size of inguinal fat pad isolated from female mice that have been fed with HFD and 7,8-DHF for 20 weeks (n = 4).

(E) Circulating leptin concentration in female mice that have been fed with HFD and 7,8-DHF for 20 weeks (*P < 0.05, Student's t test, n = 6).

(F) Circulating TNFα concentration in female mice that have been fed with HFD and 7,8-DHF for 20 weeks (*P < 0.05, Student's t test, n = 6).

(G) Tissue cholesterol content in female mice that have been fed with HFD and 7,8-DHF for 20 weeks (*P < 0.05, Student's t test, n = 6).

(H) Tissue TG content in female mice that have been fed with HFD and 7,8-DHF for 20 weeks (**P < 0.01, Student's t test, n = 6).

(I) Tissue FFA content in female mice that have been fed with HFD and 7,8-DHF for 20 weeks (**P < 0.01, Student's t test, n = 6). See also Figures S1 and S2. Results were presented as means ± SEM.