Table 1.

Glycemic measurements in juvenile Ossabaw pigs fed a HA diet.

HA DIET DURATION	0-month	2-month	3-month	4-month	5-month	6-month	7-month
Fasting:
Plasma Glucose (mg/dL)	108 ± 10	99 ± 2	87* ± 2	83** ± 3	98 ± 10	86* ± 1	85* ± 5
Plasma Insulin (µU/ml)	13 ± 6	12 ± 2	11 ± 1	10 ± 1	23* ± 4	12 ± 0	18 ± 3
QUICKI	0.334 ± 0.021	0.329 ± 0.004	0.338 ± 0.007	0.345 ± 0.004	0.301* ± 0.012	0.332 ± 0.000	0.317 ± 0.01
HOMA-BCF%	93 ± 21	121 ± 26	163 ± 13	192* ± 44	252*** ± 35	190* ± 6	305*** ± 53
IVGTT:
AUCglucose/AUCinsulin	7.23 ± 1.96	5.53 ± 0.26	3.64** ± 0.51	4.19* ± 0.68	3.03** ± 0.17	2.97** ± 0.83	2.91** ± 0.08
BCF (pmol/mmol)	12.50 ± 3.56	11.34 ± 0.37	14.05 ± 2.13	13.52 ± 0.87	16.42 ± 1.50	15.59 ± 3.27	17.05 ± 2.35
KG (min−1)	6.37 ± 0.42	3.72** ± 0.23	4.41* ± 0.53	4.17* ± 0.42	4.20* ± 0.33	4.67* ± 0.84	3.01*** ± 0.37
S2 (ml•min−1•pM•kg−1)	6.78 ± 1.19	2.50*** ± 0.21	1.93*** ± 0.20	1.77*** ± 0.27	1.37*** ± 0.05	1.14*** ± 0.08	0.85*** ± 0.12
DI	2056 ± 193	756*** ± 76	773*** ± 57	741*** ± 77	705*** ± 76	642*** ± 62	485*** ± 41

HA diet = hypercaloric atherogenic diet; QUICKI = quantitative insulin sensitivity check index; HOMA-%BCF = homeostasis model assessment for steady state beta cell function; AUC = area under curve for glucose and insulin; BCF = beta cell function; K_G = glucose tolerance; S2 = insulin sensitivity index; DI = disposition index. Equations for each glycemic measure are described in the Calculations section in Methods and Materials. Data shown are mean ± SEM.

^*= P<0.05,

^**= P<0.01,

^***= P<0.001 from baseline values (0-month).