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Core body temperature (A) and survival rate (B) of BALB/c and Rag2−/− mice receiving an LPS dose of 5 mg/kg of body weight. Statistical analysis by two-way ANOVA for temperature revealed main effects for time (p < 0.0001) and genotype (p = 0.0043). Statistical comparisons for survival by Log Rank (Mantel Cox) test showed a significant effect (p = 0.0143), with a median survival time of 24 hr for Rag2−/− mice.
