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Zac1-dependent transcriptional regulation of imprinted genes. Zac1 binds to the downstream enhancer of H19 and transactivates H19 and Igf2 expression in neuronal cells. In pancreatic progenitor cell, Zac1 bind to the promoter of the paternally imprinted Rasgrf1 gene and confers repression. Following neuronal differentiation of NSCs, Zac1 induces Tcf4, which binds at the promoter of the imprinted p57Kip2 gene and enhances G1 cell cycle arrest.
