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Homing of MNC: the SDF1-CXCR4 axis. MNC circulate through the vasculature or are retained by high SDF1 in bone marrow and spleen. Upon ischemia or tissue damage, SDF1 is released into the bloodstream creating an attracting gradient for MNC. The MNC home toward the damaged tissue via this gradient. This process is negatively regulated by DPP4.
