Table 2.

Congestion and quality of life by tertiles of baseline galectin-3 levels

	Low Gal-3 Tertile (N=69)	Mid Gal-3 Tertile (N=70)	High Gal-3 Tertile (N=69)	p-value	p-value†	p-value‡
NYHA class II	37 (54)	31 (44)	29 (42)	0.35	0.77	0.74
MLHFQ Score (n=200)	44 (31 – 66)	46 (32 – 61)	40 (25 – 57)	0.30	0.80	0.66
Elevated JVP (n=202)	28 (42)	30 (44)	33 (49)	0.69	0.80	0.91
Rales present	2 (3)	5 (7)	7 (10)	0.23	0.53	0.60
S3 present	3 (4)	3 (4)	2 (3)	1.00	0.94	0.95
≥ Moderate edema	6 (9)	15 (21)	20 (29)	0.01	0.12	0.12
Orthopnea (n=194)	34 (53)	41 (64)	47 (71)	0.10	0.35	0.43

Data are median (IQR) or n (%); Data available in all 208 participants except as noted

^†Adjusted for Age, Sex, cystatin-C;

^‡Adjusted for cystatin-C alone

Abbreviations: JVP, Jugular Venous Pressure; MLHFQ, Minnesota Living with Heart Failure Questionnaire; NYHA, New York Heart Association; S3; S3 Gallop