Table 3.
Baseline cardiac structure and function by tertiles of baseline galectin-3 levels
| n‡ | Low Gal-3 Tertile (N=69) |
Mid Gal-3 Tertile (N=70) |
High Gal-3 Tertile (N=69) |
p-value | p-value w† | p-value‡ | |
|---|---|---|---|---|---|---|---|
| Echocardiography | |||||||
| LVEDd/BSA, cm/ m2 | 157 | 2.2 (2.1 – 2.5) | 2.2 (2.0 – 2.4) | 2.2 (2.0 – 2.4) | 0.96 | 0.96 | 0.98 |
| Relative wall thickness | 151 | 0.38 (0.35 – 0.44) | 0.40 (0.34 – 0.51) | 0.45 (0.40 – 0.52) | 0.006 | 0.71 | 0.73 |
| LV mass/BSA, g/m2 | 151 | 75 (63 – 88) | 77 (63 – 91) | 80 (60 – 102) | 0.78 | 0.97 | 0.93 |
| LV mass / height1.7, g/m1.7 | 151 | 63 (52 – 76) | 67 (54 – 84) | 66 (54 – 88) | 0.64 | 0.91 | 0.85 |
| Ejection fraction, % | 205 | 61 (57 – 65) | 60 (55 – 67) | 60 (56 – 65) | 0.47 | 0.66 | 0.66 |
| E/A ratio | 137 | 1.2 (1.0 – 2.0) | 1.5 (1.0 – 2.0) | 1.3 (0.9 – 2.0) | 0.55 | 0.23 | 0.34 |
| Medial e', m/sec | 190 | 0.06 (0.05 – 0.07) | 0.06 (0.05 – 0.09) | 0.06 (0.04 – 0.08) | 0.22 0.17 | 0.13 0.99 | 0.20 |
| Medial E/e' | 181 | 14.6 (10.0 – 20.0) | 15.7 (12.0 – 22.3) | 17.5 (13.3 – 25.0) | 0.94 | ||
| Deceleration time, ms | 186 | 181 (155 – 219) | 190 (158 – 215) | 183 (153 – 220) | 0.95 0.48 | 0.94 0.59 | 0.96 |
| LA volume/BSA, mL/m2 | 144 | 43 (33 – 59) | 42 (34 – 58) | 46 (38 – 59) | 0.84 | ||
| PASP, mmHg | 131 | 41 (35 – 54) | 37 (30 – 49) | 45.(35 – 51) | 0.19 | 0.24 | 0.26 |
| CMRI | |||||||
| LVEDV / BSA, mL/ m2 | 115 | 55 (46 – 64) | 56 (44 – 67) | 59 (51 – 71) | 0.46 0.17 | 0.69 0.62 | 0.70 |
| LV mass/LV volume, g/ml | 115 | 1.19 (1.00 – 1.47) | 1.05 (0.86 – 1.40) | 1.05 (0.98 – 1.46) | 0.17 | ||
| Ejection fraction, % | 115 | 68 (57 – 71) | 66 (64 – 70) | 0.70 0.33 | 0.25 0.54 | 0.22 | |
| LV mass/BSA, g/m2 | 115 | 65 (57 – 69) | 60 (52 – 72) | 65 (55 – 77) | 0.090 | ||
| LV mass / height1.7, g/m1.7 | 115 | 64 (54 – 83) | 51 (45 – 61) | 59 (46 – 71) | 0.26 | 0.56 | 0.056 |
| Vascular Function | 57 (46 – 73) | ||||||
| Systolic BP, mmHg | 208 | 126 (116 – 137) | 128 (112 – 142) | 124 (112 – 138) | 0.81 | 0.81 | 0.73 |
| Diastolic BP, mmHg | 208 | 70 (65 – 80) | 72 (64 – 78) | 67 (60 – 74) | 0.020 | 0.46 | 0.37 |
| Ao distensability, 10−3 mm Hg−1 | 85 | 1.22 (0.70 – 1.64) | 1.20 (0.71 – 2.97) | 1.00 (0.58 – 1.76) | 0.63 | 0.042 | 0.59 |
Data are median (IQR); ‡ total n with data
†
Adjusted for Age, Sex, cystatin-C;
‡
Adjusted for cystatin-C alone
Abbreviations: Ao, Aortic; CMRI, Cardiac Magnetic Resonance Imaging; LA, Left Atrium; LVEDd, Left Ventricular End Diastolic Dimension; LVEDV, Left Ventricular End Diastolic Volume; PASP, Pulmonary Artery Systolic Pressure