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. 2015 Mar 23;5:9386. doi: 10.1038/srep09386

Figure 5. Module and protein variance of chromosomal passenger complex (CPC) supermodule during cell division.

Figure 5

Based on 87 gene expression sets, the CPC supermodule, including six genes for BIRC5, AURKB, CDCA8, INCENP, XPO1, and EVI5, consists of 4 modules that were described in more than three gene expression sets. For example, modules 1 and 2 are presented in 8 and 4 sets, respectively. The CPC supermodule can represents the dynamical regulation of cell division in interphase state and mitotic state, comprised of prophase, prometaphase, metaphase, anaphase and telophase (not represented here). Based on gene expression sets, the co-expressions of 9 PPIs in the CPC supermodule are measured using Pearson's r values ranging from −1 (green) to 1 (red). Proteins and PPIs with low gene co-expression (Pearson's r < 0.5) are shown as gray circles and gray lines. Other proteins and PPIs are indicated with blue circles and black lines. For example, for module 1, Pearson's r values of the three PPIs AURKB–BIRC5, AURKB–CDCA8, and BIRC5–CDCA8 are more than 0.5 (red). Solid circles/lines denote core proteins/PPIs, and dashed circles/lines denote ring proteins/PPIs.