Table 2.
Univariate and multivariate Cox proportional-hazards regression models of cerebrovascular accidents in patients with pituitary adenoma
| Variables | No. of patients | HR* (95% CI, P value) | HR** (95% CI, P-value) |
|---|---|---|---|
| Age (years) | |||
| >60 | 30 | 11.93 (6.26–23.03 <.0001) | 152.58 (26.88–343.71, .0001) |
| <60 | 113 | Ref | Ref |
| Sex | |||
| Male | 55 | 3.67 (2.03–6.84, <.0001) | 1.43 (0.29–7.28, .66) |
| Female | 88 | Ref | Ref |
| Tumor size | |||
| Microadenoma | 35 | 0.54 (0.18–1.25, .16) | n/a |
| Macroadenoma | 108 | Ref | |
| Treatment | |||
| Conservative | 59 | 1.28 (0.70–2.30, .42) | n/a |
| Nonconservative | 84 | Ref | |
| Surgery | 76 | 0.75 (0.42–1.33, 0.32) | n/a |
| No surgery | 67 | Ref | |
| RT | 29 | 1.23 (0.64–2.27, .53) | 2.97 (0.41–63.43, .31) |
| No RT | 114 | Ref | Ref |
| Surgery plus RT | 21 | 1.17 (0.55–2.26, .67) | n/a |
| Not combination of surgery plus RT | 122 | Ref | |
| Repeat RT | 5 | 3.41 (1.05–9.68, .04) | 5.38 (0.84–37.49, .07) |
| No repeat RT | 138 | Ref | Ref |
| Less than GTR | 26 | 1.11 (0.44–2.64, .82) | 1.07 (0.15–9.13, .94) |
| GTR | 50 | Ref | Ref |
Abbreviations: GTR, gross total resection; HR, hazard ratio; Ref, reference variable; RT, radiotherapy.
*univariate analysis.
**multivariate analysis.