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. Author manuscript; available in PMC: 2015 Mar 23.
Published in final edited form as: Cancer Cell. 2009 Nov 6;16(5):369–377. doi: 10.1016/j.ccr.2009.09.024

Figure 1. Schematic of RP-MDM2-p53 pathway regulation by nucleolar stress.

Figure 1

Under normal growth conditions (no stress), small (S, 40S) and large (L, 60S) RPs are assembled in the nucleolus (NO) and transported to the cytoplasm (CP) for protein synthesis. Under nucleolar stress, ribosomal biogenesis is inhibited and Ribosome-free forms of RPs (RPL and RPS) enter the nucleoplasm (NP) to interact with MDM2, resulting in p53 stabilization and activation. Similarly, RPs either released from breaking down (indicated by wavy edges) of cytoplasmic Ribosomes or overproduced in the cytoplasm can enter the nucleoplasm to interact with MDM2.